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Dr. Seftel
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| The research program in sexual dysfunction encompasses both
clinical and basic science projects. Clinically, research programs include
testing of novel alternate uses of sildenafil; phase 2 and 3 trials of various
oral and topical therapies for erectile dysfunction (ED); evaluation of
sleep disorders and hypoxia as they relate to ED; and clinical trials of new
testing devices for ED. Collaborative research projects include evaluation of
sperm for chromosomal abnormalities for male factor infertility and examining T
cells for autoimmune prostatitis. |
| The basic science research focus is centered on understanding the
mechanisms of diabetes-related ED. Rat, rabbit and human tissue are used
in effort to understand how diabetes affects the nitric oxide pathway of
erections. A second project investigates diabetes's effects on nitric oxide
synthase, protein kinase C or collagen deposition. A related project evaluates
the hypoxic mechanisms of ED in a rat model in collaboration with our pulmonary
division. |
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