City College of New York, New York  

Degree:  B.S., Biology

1965-69

University of Kentucky College of Medicine 

Lexington, Kentucky

1969-71

Summer Fellowship in Neurology, Department of  Neurology

Boston University School of Medicine, Boston, MA

1970

Mount Sinai School of Medicine    

City University of New York, New York, NY

1971-73

M.D.

June 1973

Straight Medicine Internship 

Beth Israel Hospital, New York, New YorK

1973-74

Neurology Residency and Chief Residency

Mount Sinai School of Medicine, New York, New York

1974-77

Weatherhead School of Management, CWRU

Member, Professional Fellows Program (15 credits)

1992-1993

Banking & Finance 420: Health Finance & Economics (3 credits)

1993

Health Systems Management 456:  Issues in Health Management (3 credits)

1994

Diplomate, National Board of Medical Examiners                          

1974

Certified, American Board of Psychiatry and Neurology                

1979

California, Physician and Surgeon (GO 39005)                               

1980-1995

California, Physician and Surgeon (GO 39005)

1986-91

Maryland, Physician and Surgeon (D33237)                                  

1988-91

District of Columbia, Medicine and Surgery (17144)                      

1988-91

Ohio, Doctor of Medicine (35-05-9810)                                         

1990-Present

Research Fellow, National Institutes of Health

(Senile Dementia: Biological and Behavioral Aspects)

Albert Einstein College of Medicine, New York, New York

1977-78

Associate, Department of Neurology
Albert Einstein College of Medicine, New York, New York
Clinical Study of Aging, Dementia and Cerebral Blood Flow (133 Xe Inhalation)

1977-78

Assistant Attending Neurologist 

Lincoln Hospital, Bronx, New York

1977-78

Clinical Fellow       

Jacobi Hospital, Department of Neurology, Bronx, New York

1977-78

 

Assistant Professor of Neurology, in Residence

University of California, Davis

1978-85

Associate Professor of Neurology, in Residence

University of California, Davis

1985

Staff Neurologist     

Veterans Administration Medical Center, Martinez, California

1978-85

Assistant Chief, Neurology Service

Veterans Administration Medical Center, Martinez, California

1978-84

Attending Neurologist, Highland General Hospital

Oakland, California

1979-85

Guest Scientist, Donner Laboratory 

University of California, Berkeley

1979-85

Chief Neurologist      

Research Medicine Group Donner Laboratory

University of California, Berkeley

1982-85

Director and Founder, Northern California Alzheimer's

Disease Center, University of California Davis, Berkeley, California

1985

Chief, Brain Aging and Dementia Section 

Laboratory of Neurosciences, National Institute on Aging, NIH

1986-1990

Deputy Clinical Director

National Institute on Aging

1986-1990

Clinical Professor 

Department of Neurology

Georgetown University School of Medicine

1988-1990

Director, Alzheimer's Disease and Memory Disorders Clinic    

Georgetown University Hospital

1988-1990

Clinical Director

1990-1993

Acting Director

1993

Associate Director 

NIA Alzheimer's Disease Research Center

University Hospitals of Cleveland

1994

Associate Professor 

1990-2001

Professor   

Departments of Neurology, Psychiatry and Radiology

Case Western Reserve University School of Medicine

2001-present

Chief, Laboratory of Neurogeriatrics  

Department of Neurology

Case Western Reserve University School of Medicine

1994-Present

Medical Advisor and Member, Board of Directors                        

Alzheimer’s Aid Society of Northern California

1983-85

Member, Scientific Advisory Committee

Family Survival Project, San Francisco

1984-1995

Chief Witness, California Assembly Select Committee                  

on Mental Health, Hearing on "Organic Brain Syndromes," State Capital, Sacramento

1984

Member, Ad Hoc Committee to Consider a National                     

Conference on Neurological Disease and Aging, Special Committee on Aging, U.S. Senate

1986

Consultant, WNET/Thirteen, New York

1988

Member, Neuroscience Advisory Panel, Conte Institute for Environmental Health, Pittsfield, MA

1993-1994

Consultant, Dementia and Driving Consensus Meeting, Swedish National Road Administration, Borlange

1994

Ad Hoc Reviewer of Research Programs

Research Service, VA Central Office

1984, 1986, 1988, 1989, 1991, 1993-95

Division of Research Grants, NIH

1987-1995, 1997, 1998

Human Frontier Science Program(EEC, Strasbourg)

1991, 1991-1993,1997

Edison Biotechnology Center

1992

Retirement Research Foundation

1993

Netherlands Organization for Scientific Research

1994

Alzheimer Association

1994, 1996-1999

British Columbia Health Research Foundation

1995, 1999

American Federation for Aging Research

1995-present

The National Institute for Psychobiology in Israel 

1998, 2002

Special Emphasis Panel, NIH, CSR

1998

Warrant Committee, Italian Ministry of Research

1998

Douglas French Foundation, Los Angeles

2002

Principal Investigator, "Effect of activation of ischemic neurons on recovery from stroke", University of California, Davis, Faculty Research Grant

1979-81

Principal Investigator, VA Merit Review Research Program, 

"Cerebral Metabolic Indices of Dementia Pathophysiology"

1981-84

Principal Investigator, (Renewal of above Program) "Structural and Functional Indices of Dementia Pathophysiology" ($47,337/year)

1984-85

Co-Investigator, "Ischemic Brain Disease," (NIH HL 25840), ($34,192/year), Principal Investigator, Philip Weinstein, M.D.

1983-85

Co-Investigator "Cerebral blood flow patterns in Alzheimer's disease", (NIH), ($187,000/year) Principal Investigator, Thomas F. Budinger, M.D., Ph.D.

1985

Principal Investigator, "Oxiracetam in the treatment of progressive degenerative dementia of mild to moderate severity", Ciba-Geigy Corporation ($67,000)

1985

Project Director and Founder "Northern California Alzheimer's Disease Center," Department of Health Services, State of California ($100,000/year)

1985

Chief, Brain Aging and Dementia Section 

National Institute on Aging, NIH  ($2.4 million/year) 

1986-1990

Director, Clinical Core

1990-1993

Acting Director

1993

Co-Director Clinical Core 

Alzheimer's Disease Research Center

University Hospitals of Cleveland NIA AG08012 ($1,386,582/year)

1994

Co-Investigator, Clinical Research Center for the Psychopathology of the Elderly NIMH MH43444 ($100,000/year)

1990-1991

Principal Investigator, Monoclonal antibodies for the immunochemical evaluation of Alzheimer's Disease

 - NIA ADRC Pilot grant ($22,150)

1990-1992

Co-Investigator, State of Ohio Center Grant "Causes and Treatments of Alzheimer's Disease" ($265,909/year)

1990-1992

Lawrence C. McHenry Award 

American Academy of Neurology

1990

Director Consortium to Establish a Registry for Alzheimer's

Disease Clinic (CERAD), Cleveland, NIA

1990-1996

Principal Investigator, "A Placebo Controlled Study of Acetyl-L-Carnitine in Patients with Alzheimer's Disease: A Multi-Center Study," Sigma-Tau Pharmaceuticals, Inc. ($140,000)

1991-1994

Principal Investigator (45%) “The effects of cigarette smoking on the development of Alzheimer's disease:  Epidemiological, Clinical and Neurobiological Studies."  Philip Morris USA

($6,989,078 Direct & Indirect Costs, 1991-1996)

1991-1996

Principal investigation (40%) "The effects of cigarette smoking  on the development of  Alzheimer’s disease: International epidemiological and neurobiological studies.” Philip Morris, USA,

(Jan. 1997-Dec.  2001) $9,809,202 (Direct and Indirect costs)                  

1997-2001

Principal Investigator (20%) “Monoclonal antibody imaging of cerebral Aß in Alzheimer’s disease,” Philip Morris USA ($59,103 Direct costs per year)

1991-1996

Sponsor, IND-BB-5059, "Technetium 99mTc Murine monoclonal antibody 10H3 Fab," Food and Drug Administration (Collaboration with the Massachusetts General Hospital, Mallinckrodt Medical and NeoRx Corporation) 

1994

Saul Horowitz, Jr. Memorial Award

Mt. Sinai School of Medicine, New York, New York

1994

Co-Investigator, "The effect of lazabemide on regional brain monoamine oxidase type B activity in patients with Alzheimer's Disease as measured by ¹¹C-L-Selegiline positron emission tomography,"  Hoffmann-LaRoche, Inc.

1994-1995

Principal Investigator: “Cross-Cultural (Cleveland-Israel) studies of the basic and clinical sciences of Alzheimer's disease,” [(Joseph and Florence Mandel Foundation ($150,000)] 

1995-98

Principal Investigator: "A population based prevalence study of genetic and environmental factors for Alzheimer’s disease in Kenya”, Alzheimer’s Association (Chicago) - ($68,000 per year, direct and indirect costs)

1997-2000

Principal Investigator:  “Noninvasive imaging of cerebral amyloid-ß deposition in Alzheimer’s disease,” Nickman Family gift to University Hospitals of Cleveland ($250,000).        

1997-2003

Principal Investigator: CWRU Site, Multi-institutional Research on Alzheimer Genetic Epidemiology, NIA Grant (L. Farrer, PI)

1998-2008

Principal Investigator: Israel and Alzheimer’s disease, Epidemiology, Demography and Biometry Program, NIA, NIH, Contract #263-MO-818915, $22,950 (total costs)

1998-1999

Principal Investigator: "Genetic and environmental risk factors for Alzheimer’s disease in Israeli Arabs”, $50,000, Institute for the Study on Aging, New York, New York.

1999-2000

Principal Investigator: "Genetics of Alzheimer’s Disease in Israeli Arabs,” National Institute of Health, National Institute on Aging, NIH, $474,753 (total costs for year one) UO1 AG1713-01A1

     Renewal  resubmitted 11/03 ($5,807,317 total costs for           2003-2008)

NIH/NIA  Data Sharing Administrative supplement funded,      $77,1000 total costs, 9/1/03

2000-2003

Principal Investigator: "Genetic and environmental factors for Alzheimer’s disease in Israeli Arabs”, Institute for the Study of Aging, NY, (3 years, direct costs $210,000)

2000-2003

Principal Investigator, "First International Symposium on Alzheimer’s Disease in the Middle East” NIH R13 grant, (total costs $10,000) Institute for the Study of Aging, NY,  $30,000

2001-2002

Principal Investigator: "Family based studies of gene-environment

Interactions in Alzheimer’s disease” Philip Morris External Research Program, $2,111,035 total costs

2002-2005

Convener and primary organizer, Second International Symposium on Alzheimer’ s Disease in the Middle East, Istanbul, Turkey, May, 2003, National Institute on Aging (R13 AG021082-01A1), and  Alzheimer Association, USA ($89,000 direct costs).

2002 (pending)

Principal Investigator: “Labeling of cerebral ABeta deposits in vivo using intranasal administration of serum amyloid P component”

Presidential Technology Development Grant Program, CWRU

$50,000 direct costs

2002-2003

Principal Investigator, Unrestricted gift to CWRU for research support, $25,000, GOJO Corp., Akron, OH.

2003-2005

Principal Investigator, The First Congress of the International Society for Vascular Behavioral and Cognitive Disorders (Vas-Cog 2003) Goteborg, Sweden, August 28-31, 2003, NIH R13, $30,000 direct costs

2003-2004

Principal Investigator: Molecular epidemiology and neurobiology of anti-Abeta antibody-antigen interactions in Alzheimer’s disease”  Fullerton Family Foundation (Gift to CWRU), $300,000 direct costs

Principal Investigator, CWRU site, Multi-institutional Research in Alzheimer’s Genetic Epidemiology (MIRAGE) (L. Farrer, PI), $55,000/year direct costs, NIA, NIA

Principal investigator, Alzheimer’s disease African–American Education Program, Pfizer Corp., $43,000 total costs.

2002-2005

 2002-2007

2004-2005 

Participation in Neurosciences Course       

University of California, Davis  (First and second year students)

1977-85

Instruction of medical students in Clinical Neurology

University of California, Davis

(Third and fourth year students)

1977-85

Supervisor of Neurology Residency Training Program   

University of California, Davis, Martinez VAMC Participation on Doctoral Qualifying Examination Committees, University of California, Berkeley

1977-82

Biophysics and Medical Physics

1981

Physiological Optics

1984

Instructor, Graduate Interdisciplinary Studies Course, IDS 271, "Seminars in Neuropsychology" (4), Department of Psychology, University of California, Berkeley

1981, 1982

Instructor, Graduate Interdisciplinary Studies Seminar on Memory Pathology, Department of Psychology, University of California, Berkeley

1983

Visiting Professor, Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky

1988

Course Coordinator, Neurobiology of Aging and Dementia, Clinical Elective for 3^rd and 4^th year medical students, Clinical Center, NIH

1985-1990

Course Coordinator, Type A Elective, Alzheimer's disease:  From biology to clinical medicine, CWRU School of Medicine

1992-present

Course Coordinator - Type A Elective -DGMS-2002 Critical Thinking for Clinical Medicine, CWRU School of Medicine

1995- present

Participation on Doctoral Qualifying Examination Committee, CWRU Department of Pathology 

1992-1995

Participating speaker, CWRU:

GEMD 3002: The Physiology of Aging

1994-present

Anthropology 215: Health Culture & Disease Introduction to Medical Anthropology

1996-present

Philosophy 101, Introduction to Philosophy

1999

Participant, CWRU School of Medicine Prematriculation Program

1997

Applicant Interviewer, CWRU School of Medicine 

1997-present

Member, Admissions Committee, CWRU School of Medicine

2000-present

Member, Dissertation Committee, Heather A. Lindstrom-Ufuti: "Determinants of Social Status in the Elderly. A field study in American and Western Samoa,” CWRU Department of Anthropology 

1999-present

Course Director:  "Alois Alzheimer and his Friends,” American Academy of Neurology Educational Program, Annual Meeting, Philadelphia

Member, Dissertation Committee, Abdalla Bowirrat, MD, Tel Aviv University, Dept. of Neurology, “Epidemiological and Genetic Studies of Alzheimer type Dementia in an Elderly Arab Population in Israel”

2000

2001

External Thesis Examiner, N. Cookson, University of Newcastle, Faculty of Medicine, MPh.

2002

Mentor, Independent Studies, CWRU graduate students in Epidemiology and  Biostatistics

2004

VA Medical Center, Martinez

Quality Assurance Committee

1978-85

Neurology Service Quality Assurance Committee (Chairman)

1984-85

Pharmacy and Therapeutics Committee

1979-82

Library Advisory Committee (Vice-Chairman)

1978-84

Research and Development Committee

1985

Lawrence Berkeley Laboratory

1980-85

University of California, Berkeley Pituitary Tumor Board 

University of California, Davis School of Medicine

1982-85

Admissions Committee

National Institutes of Health

Clinical Center Medical Board

Subcommittee on Promotions

1986-1990

PET Steering Committee (Secretary)

1987-1989

Case Western Reserve University/University Hospitals of Cleveland

ElderHealth Center Advisory Committee

1990-1994

Subcommittee on Neurology Resident Education

1991-Present

Department of Neurology, Credentials Committee

1991-Present

Committee on Appointments, Promotion and Tenure

1995-Present

Pharmacy and Therapeutics Committee

Center on Aging and Health,

1991-1992

       Senior Faculty Associate, member

       Development Committee

1991-Present

           1999-Present

CWRU/Henry Ford Hospital Affiliation Committee

1992-1994

Flexible Elective Committee

1995-Present

Neurology Coordinator, Generalist Initiative

1995-Present

Department of Neurology -Investigational Review Committee

(Chair)

1995-1996

Radiation Safety Committee

1996-Present

Radioactive Drug Research Committee

1996 -Present

Primary Care Track Committee

1996-Present

Admissions Committee (SOM)

2000-Present